POISED TO ADVOCATE

Poised to migrate

Hearts grow with the flow properly formed heart comes only after effort—the pumping of cells through a primitive heart to generate gene-activating shear forces. who have come up with a method for watching heart development by culturing developing zebrafish on microscope stages. The researchers tracked the movement of blood cells against the background of fluorescently stained blood serum. High-...

Power to advocate for health.

This is the seventh and fi nal editorial in a series about integrative approaches to promoting health and personalized, high-value health care.1-6 This editorial examines how we can develop the power to act on key values, knowledge, and principles to advance health for people, communities, and the population. This article asks the following questions: 1. What is moral authority and why is it im...

Protein kinase C: poised to signal.

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are poised to transduce signals emanating from the cell surface. Cell membranes provide the platform for PKC function, supporting the maturation of PKC through phosphorylation, its allosteric activation by binding specific lipids, and, ultimately, promoting the downregulation of the enzyme. These regulatory mech...

Hormesis: A Brief Reply to an Advocate

In his commentary in Environmental Health Perspectives, Calabrese (2009) offered a num­ ber of responses to my critique of hormesis methodology (Mushak 2009). Here I will provide a counterpoint to that effort. • Calabrese (2009) falsely asserted that I erred in calculations associated with entry and evaluatory criteria for hormesis frequency, specifically by choosing the wrong denomi­ nator for...

Advocate for our patients.